ea0032p622 | Growth hormome IGF axis – basic | ECE2013
Frystyk Jan
, Gude Mette Faurholdt
, Hjortebjerg Rikke
, Oxvig Claus
, Pedersen Steen Bonlokke
Background: Visceral adipose tissue (VAT) is less insulin sensitive and more harmful than subcutaneous adipose tissue (SAT). In adipocytes, IGF1 receptor signaling has been linked to insulin resistance, but it is unknown whether VAT and SAT also differ in production of IGFs. Therefore, we compared IGFs, IGFBP-4 and PAPP-A production in cultured fragments of VAT and SAT from obese subjects.Methods: VAT and SAT was collected perioperatively during elective...